The warning says that estrogens with or without progestins should not be used for the prevention of cardiovascular disease. Included in the warning box is risk information derived from the Women's Health Initiative (WHI) study which found increased risks of:
- myocardial
infarction
- stroke
- invasive
breast
cancer
- pulmonary
emboli
- deep vein thrombosis.
The study included postmenopausal women who were treated for five years with conjugated equine estrogens (0.625 mg) combined with medroxyprogesterone acetate (2.5 mg) relative to placebo.
Because of these risks, health care providers should prescribe estrogens with or without progestins at the lowest effective dose and for the least amount of time required to acheive individual risk and treatment goals for each woman.
Dear Health Professional Letter
Source: FDA/CDER
