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Updated June 19, 2014

Definition: Progestin is the generic name for synthetic progesterone. Progesterone is produced by the ovaries during the menstrual cycle. Oral contraceptives contain progestin. Progestin is also combined with estrogen in prescription skin patches for use as hormone replacement therapy (HRT) during perimenopause and menopause. Progestin therapy is not recommended for women who no longer have their uteri. Progestin therapy may also be prescribed for women experiencing abnormal uterine bleeding.
Progestin replacement during menopause helps protect the uterus from endometrial cancer.

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